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中文摘要：
TRP（transient eceptor otential）离子通道是一类广泛存在于细胞膜上的跨膜蛋白质，可以辨别酸甜苦辣等各种味觉和温暖、冷、热等各种温度觉。TRP通道亚型TRPM8最初作为一种前列腺特异性蛋白被克隆出来，并可在热敏反应中被冷刺激和薄荷醇激活。TRPM8可以感知温度觉和痛觉，并可缓解疼痛，具有重要的研究意义。该文拟就当前TRPM8的生物物理学、门控机制和这类TRP通道的药理及病理生理机制等进行综述。
英文摘要：
TRP （transient receptor potential） ion channel is a kind of membrane proteins which are widespreadly present in various cells, which is used to identify various mixed flavor and warm,heat, cold, and other temperature. Originally cloned as a proatate-specific protein. TRPM8 is now best known as a coldand menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and （patho） physiology of this TRP channel .
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