二烷基锌对醛的不对称加成反应是合成手性二级醇的有效方法,产物手性二级醇是药物、精细化学品和天然产物的重要中间体,以不同结构类型的手性配体为依据,综述了近6年来各种手性配体在醛的不对称烷基化反应中的应用.
Asymmetric addition of dialkyzinc to aldehyde was a successful method for synthesis of chiral secondary alcohols, which were valuable buildings blocks for pharmaceuticals, fine chemicals and natural products. Research developments in the asymmetric alkylation of aldehydes are reviewed according to different structure types of chiral ligands.