中文摘要：

引言 丁二酸（butanedioic acid）作为C1平台化合物，可以用于合成1，4-丁二醇、四氢呋喃、γ-丁内酯等有机化学品以及聚丁二酸丁二醇酯（PBS）类生物可降解材料，被美国能源部认为是未来12种最有价值的生物炼制产品之一。微生物发酵生产丁二酸具有利用可再生资源、固定温室气体CO2等优点，近年来成为国内外研究的热点，

英文摘要：

The fermentation process of butanedioic acid by Actinobacillus succinogenes NJ113 with glucose as substrate was studied in batch system.Kinetic models were proposed based on the Levenspiel and Luedeking-Piret equations of cell growth,product formation and substrate consumption.With the correlated model parameters,the model could provide reasonable description for the fermentation process at various glucose concentrations.From the kinetic analysis,the microbial growth of Actinobacillus succinogenes NJ113 gradually slowed down with increasing amount of organic acids,and the growth completely ceased when the amount of organic acids exceeded 23.435 g·L-1.Above this critical value,the concentration of biomass declined linearly with the rate of 0.024 h-1 and the productivity of metabolite also decreased as the fermentation proceeded.The models proposed could be used for the development and optimization of butanedioic acid production processes.