中文摘要：

目的：探讨早期强化阿托伐他汀治疗对急性冠脉综合征（ACS）患者新蝶呤（Npt）、基质金属蛋白酶-9（MMP-9）的影响。方法：ACS患者121例随机分为普通治疗组59例（阿托伐他汀剂量20mg/d）,强化治疗组62例（阿托伐他汀剂量80mg/d）,比较两组治疗前、治疗后24小时、72小时、1周Npt、MMP-9水平;比较两组1周内的心血管事件发生率。结果：普通治疗组1周内心血管事件发生率明显高于强化治疗组（P〈0.01）;治疗前两组血清Npt、MMP-9水平比较,差异无统计学意义（P〉0.05）;与治疗前相比,治疗后24h两组血清Npt、MMP-9比较差异无统计学意义（P〉0.05）;治疗72h普通组的血清Npt、MMP-9与治疗前比较,差异无统计学意义（P〉0.05）,强化组血清Npt、MMP-9与治疗前比较,差异有统计学意义（P〈0.05）;治疗1周两组Npt、MMP-9水平与治疗前比较,差异有统计学意义（P〈0.01）,且强化组下降幅度大于普通组（P〈0.05）。结论：早期强化他汀治疗能够有效减少ACS患者近期心血管事件的发生,其作用可能与降低Npt、MMP-9水平,抑制炎症反应有关。

英文摘要：

Objective：To investigate the effects of early intensive atorvastatin therapy on the levels of neopterin（Npt） and Matrix metalloproteinase-9（MMP-9） in hospitalized patients with acute coronary syndrome.Methods：121Hospitalized patients with acute coronary syndrome were randomly divided into the conventional therapy group（atorvastatin 20mg/d,n=59） and the intensive treatment group（atorvastatin 80mg/d,n=62）.All the patients were administrated with standard medicine therapy and fed with salt-poor,low-fat diet.The serum concentrations of Npt and MMP-9 were determined at four timepoints（baseline,at 24 hours,72 hours and after one week）.Cardiovascular events were monitored within a week.Results： At 72 hours,Serum concentrations of Npt and MMP-9 in the intensive treatment group decreased significantly（P0.05） in comparision with the baseline.However,these two biomarks were markedly lower in both groups of patients at one week（P〈0.01）.Compared with the conventional therapy,intensive atorvastatin therapy furtherly reduced the levels of Npt and MMP-9（P〈0.05）.The occurrence of cardiovascular events observed during hospitalization in the intensive therapy group was ignificantly lower than that of the conventional treatment group（P〈0.05）.Conclusion： Early intensive atorvastatin treatment in patients with ACS may provide an advantage over the conventional treatment,with regard to reducing cardiovascular events dependent of its influence on the concentrations of Npt and MMP-9 and effective anti-inflammation.