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淀粉/聚乙烯醇复合生物膜的制备及其表征

期刊名称：中国组织工程研究与临床康复
时间：0
页码：1414-1417
语言：中文
分类：R318[医药卫生—生物医学工程;医药卫生—基础医学]
作者机构：[1]北京化工大学材料科学与工程学院先进弹性体研究中心,北京市100029, [2]北京市创伤骨科组织工程研究所,北京市100035
相关基金：北京市自然基金资助项目“新型引导组织再生膜的制备及骨缺损修复的应用研究”（2102020）; 北京市卫生局、北京市中医管理局青年科学研究资助项目“新型引导组织再生膜的设计、制备及用于桡骨骨缺损修复探索”（2009-016）
相关项目：橡胶（弹性体）

关键词：引导组织再生膜, 聚乙烯醇, 淀粉, 多孔结构, 功能复合生物材料, 组织诱导性生物材料

中文摘要：

背景：目前还没有将淀粉/聚乙烯醇膜应用于引导组织再生技术的研究,实验结合天然高分子和合成高分子的优点制备成多孔结构的引导组织再生膜。目的：不同制备工艺条件对淀粉/聚乙烯醇膜性能的影响。方法：以聚乙烯醇和淀粉为主要原料,通过溶液浇注、冷冻干燥法制备具有多孔结构的引导组织再生膜,考察原料配比、溶液浓度和预冻温度对多孔薄膜性能的影响。对薄膜的表面形貌、孔隙率、吸水率、力学性能及细胞毒性进行了表征。结果与结论：不同工艺条件下制备膜的孔径在1-50μm,孔隙率在60%-70%,拉伸强度在12-26MPa,并且该膜具有良好的生物相容性和亲水性。当溶液浓度为5%,预冻温度为-30℃时该膜表面孔的分布比较均匀,淀粉含量越多,孔径越大。

英文摘要：

BACKGROUND：There is no study on starch/polyvinyl alcohol（PVA）as guided tissue regeneration membranes.The guided tissue regeneration membrane with porous structure were prepared,which combined with the advantages of natural polymer and synthetic polymer.OBJECTIVE：To research the effects of the preparation conditions on the properties of starch/PVA membranes.METHODS：The porous membranes of guiding tissue regeneration were prepared mainly by starch and PVA through solution mixing,casting,freezing and drying.The effects of the mass ratio of PVA and starch,solution concentration,and pre-freezing temperature on the properties of the membrane were researched.The surface morphology,tensile strength,porous ratio,water absorbance and cell cytotoxicity were characterized.RESULTS AND CONCLUSION：The aperture of the membrane was 1-50 μm,the porosity was 60%-70%,and the tensile strength was 12-26 MPa.And this membrane had the excellent biocompatibility and hydrophilicity.The pores in the surface were evenly distributed with the solution concentration of 5% and the pre-freezing temperature of-30 ℃.The more content of starch was,and the larger of the aperture was.