类型 2 糖尿病 mellitus (T2DM ) 的流行在有象不含酒精的脂肪肝疾病,长期的病毒的肝炎, hemochromatosis,含酒精的肝疾病和肝硬化那样的肝疾病的病人是更高的。在 T2DM 的存在和肝损害的严厉之间有一个病原的连接,这被建议。然而,与在 T2DM 的发展的肝的发炎的影响有关的证据还没出现了。这篇文章在肝疾病,胰岛素抵抗和房间机能障碍上的肝疾病的影响,和共存的肝疾病加重 T2DM 的发展的潜在的机制的一个范围为糖尿病的增加的流行提供证据的概述。
The prevalence of type 2 diabetes mellitus (T2DM) is higher in patients who have liver diseases such as nonalcoholic fatty liver disease, chronic viral hepatitis, hemochromatosis, alcoholic liver disease and cirrhosis. It is suggested that there is a pathogenic link between the presence of T2DM and the severity of liver injury. However, evidence related to the impact of hepatic inflammation on the development of T2DM has not yet emerged. This article provides an overview of the evidence for an increased prevalence of diabetes in a range of liver diseases, the impact of liver diseases on insulin resistance and 13 cell dysfunction, and the potential mechanisms whereby coexistent liver diseases exacerbate the development of T2DM.