目的:探讨纤维蛋白原样蛋白2(fgl2)在急性冠状动脉综合征(ACS)患者外周血单个核细胞中的表达及其意义。方法:用荧光定量PCR法检测60例ACS、25例稳定型心绞痛(SA)患者和20例正常人外周血中单个核细胞中fgl2的表达量水平。结果:ACS组fgl2基因表达明显高于SA组和正常对照组(均P〈0.05),SA组与正常对照组比较差异无统计学意义(P〉0.05)。结论:ACS患者急性期外周血单个核细胞中Igl2的表达明显增加,可能是ACS微循环障碍有预测价值的急性时相性蛋白之一。
Objective: To investigate the expression and significance of fibrinogen-like protein 2 (fgl2 prothrombinase in peripheral blood mononuclear cell (PBMC) of acute coronary syndrome (ACS) patients. Method: Fluorescence quantitative PCR was applied to detecting the expression of fgl2 in 60 ACS patients, 25 stable angina pectoris (SAP) patients and 20 normal people (CG). Result:The gene expression of fgl2 was significantly increased in ACS than SAP and CG (P〈0.05), but there was no difference between SAP and CG (P〉0.05). Conclusion: The gene expression of fgl2 of PBMC is increased in ACS patients at acute stage. It maybe a forecasting protein of acute phase in coronary artery disease especially ACS microcirculation disturbance.