中文摘要：

目的：研究Beagle犬灌胃何首乌提取物后血中移行成分及其归属。方法：通过建立灌胃何首乌提取物后Beagle犬血浆HPLC指纹图谱,比较给药及未给药Beagle犬血浆的HPLC指纹图谱,同时根据保留时间和紫外吸收光谱图判断各谱峰的相关性,进而确认灌胃何首乌提取物后Beagle犬血中移行成分及其归属。结果：给药后血浆中出现了14个移行成分,其中4个为原型成分,10个为代谢产物。结论：对血中移行成分及代谢产物的研究有助于阐明何首乌体内的药效物质基础。

英文摘要：

Objective： To investigate the plasma effective constituents of Beagle dogs after oral administration with the extract of Polygonum multiflorum thunb. Methods： Based on the established HPLC fingerprints, comparison was carried out among the blank plasma, plasma containing drug, Polygonum multiflorum thunb. Simultaneously, the retention time and UV spectrogram were utilized as index to evaluate the relation among the fingerprint peaks so as to confirm the original of peaks. Result： Fourteen components were detected after oral administration. Four of them were the original components existed in Polygonum multiflorum thunb and ten of them were metabolites. Conclusion： Studying on the constituents and metabolites in plasma is useful to research the effective substances of Chinese medicine of Polygonum multiflorum thunb in vivo.