目的 研究柳州市2015年艾滋病患者合并分枝杆菌感染状况及其耐药性.方法 将经HIV抗体筛查和蛋白免疫印迹试验确证后的1106例艾滋病患者的各类样本采用中和离心法进行分枝杆菌培养,应用PNB法进行菌种鉴定,对分离的结核杆菌和非结核分枝杆菌进行耐药性试验.统计分析柳州市2015年艾滋病患者合并分枝杆菌感染状况及其耐药性.结果 共分离出结核杆菌121株,非结核分枝杆菌27例.结核杆菌总耐药率25.6%,耐多药(耐利福平及异烟肼以上)4株,其中3株来自痰标本,1株来自脑脊液标本;非结核分枝杆菌总耐药率100%.结论 艾滋病患者身体各部位均存在感染分枝杆菌的机会,虽然耐多药比率不高,但其总耐药率很高,特别是非结核分枝杆菌,应引起广大医务人员的重视.
Objective To study the infection status and drug resistance of AIDS patients complicated with mycobacterium in Liuzhou city in 2015.Methods Neutralization and centrifugal method were used to culture mycobacterium.All kinds of samples were collected.1106 cases of AIDS patients were confirmed by HIV antibody screening and western blotting.PNB method was used to perform strain identification.Drug resistance test on separated tubercle bacillus and non-tuberculosis mycobacteria were performed.Statistical analysis was used to analyze infection status and drug resistance of AIDS patients complicated with mycobacteria in Liuzhou city in 2015.Results A total of 121 strains of tubercle bacillus and 27 non-tuberculosis mycobacteria were isolated from the mycobacterium culture in all kinds of samples of 1106 cases of AIDS patients.There were 31 drug resistance strains in all the 121 tubercle bacillus(T.B.) strains,with the total drug resistant rate of 25.6%.There were 4 multidrug-resistant strains (at least resistant to rifampin and isoniazid),3 strains from sputum and 1 strain from cerebrospinal fluid (CSF).The total drug resistant rate of those 27 non-tuberculosis mycobacteria cases was 100%.Conclusions It's possible for the AIDS patients in Liuzhou city to be infected by mycobacterium by various parts of their body.Although the multidrug-resistant ratio is relatively low,but the total drug resistant rate is very high,especially for non-tuberculosis mycobacteria.The medical professions should get the message.