成长证据表明那 beta_2-glycoprotein (beta_2GPI ) 我是为仔细与 thrombotic 事件 inantiphospholipid 症候群(APS ) 被联系的 antiphospholipid 抗体的关键目标[1 ] 。Anti-beta_2GPI/beta_2GPI 建筑群能绑在单核白血球和 endothelial 房间的表面膜,支持织物这些房间上的因素(TF ) 活动,并且因此增加血栓的风险。然而,位于行动 ofanti-beta_2GPI/beta_2GPI 下面的机制很好没被理解。效果 ofanti-beta_2GPI/beta_2GPI 要求一个信号的转导进房间并且因此,包含房间表面受体,这被建议。因为 anti-beta_2GPI/beta_2GPI 的效果不看起来被 Fc 受体,也不由细胞膜的否定地控告的 phospholipids 调停,调查者安置为 beta_2GPI 的不同房间表面受体的存在。
Dear Editor: Growing evidence demonstrates that β2-glycoprotein Ⅰ (β2GPI) is the key target for antiphospholipid antibodies which are closely associated with thrombotic events in antiphospholipid syndrome (APS) . Anti-β2GPI/β2GPI complex can bind to the surface membrane ofmonocytes and endothelial cells, promoting tissue factor (TF) activity on these cells, and thus increasing the risk of thrombosis.