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Kinetic evaluation of the size-dependent decomposition performance of solvent-free microcellular polylactic acid foams

ISSN号：1674-1056
期刊名称：《中国物理B：英文版》
时间：0
分类：TQ326.9[化学工程—合成树脂塑料工业] O631.22[理学—高分子化学;理学—化学]
作者机构：[1]Key Laboratory ofOptoelectronics of Jiangsu Province, School of Physics and Technology, Nanjing Normal University, Nanjing 210046, China, [2]Center of Analysis and Testing, Nanjing Normal University, Nanjing 210046, China, [3]College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China, [4]Institute of Acoustics, Key Laboratory of Modern Acoustics, Ministry of Education, Nanjing University, Nanjing 210093, China
相关基金：This work was supported by the National Basic Research Program of China （2011CB707900）, the National Natural Science Foundation of China （10974098）, the Natural Science Foundation of Jiangsu Province （BK2009407） and the Doctoral Fund of the Ministry of Education of China （20093207120003）.

作者： GUO GePu[1], MA QingYu[1], WANG Fang[2], ZHAO Bo[3], ZHANG Dong[4]

关键词：分解动力学, 泡沫细胞, 聚乳酸, 无溶剂, 热性能, 评价, 微孔, 寿命估计, tissue engineering scaffold, PLA foam, cell size, thermal gravimetric analysis, decomposition kinetic performance

中文摘要：

一个热 gravimetric 方法为为设计用可被细菌破坏的 polylactic 酸(PLA ) 做的脚手架的 microcellular 织物评估房间尺寸依赖者分解和一生评价的动力学被描述泡沫。从 550 ～ 20 m 的 PLA 泡沫房间尺寸从 1 ～ 5 MPa 在浸透压力下面用一种没有溶剂的固态的起泡沫技术试验性地被制作。关于房间尺寸的 PLA 泡沫的热性质在氮气氛和激活精力用热 gravimetric 分析被测量， pre 指数的因素被导出评估分解动力学和估计一生。小房间尺寸能在高浸透压力下面被完成并且 PLA 的热稳定性在制造过程以后减少，这被发现。房间尺寸依赖者热稳定性和降级率显示更大的房间尺寸的 PLA 泡沫有一更短的降级时间，一些第十 PLA 原料的，在 37 的温度

英文摘要：

A thermal gravimetric method is described for evaluating the kinetics of cell size-dependent decomposition and lifetime estimation for microcellular tissue engineering scaffolds made of biodegradable polylactic acid （PLA） foams. PLA foam cell sizes from 550 to 20 μm were fabricated experimentally using a solvent-free solid-state foaming technique under saturation pressures from 1 to 5 MPa. The thermal properties of the PLA foams with respect to the cell sizes were measured using thermal gravimetric analysis in a nitrogen atmosphere and the activation energy and pre-exponential factor were derived to evaluate the decomposition kinetics and estimate lifetime. It was found that small cell sizes can be achieved under high saturation pressures and that the thermal stability of PLA decreases after the fabrication process. The cell size-dependent thermal stability and degradation rate indicate that a PLA foam of larger cell sizes has a shorter degradation time, a few tenths that of the PLA raw material, at a temperature of 37℃ The results suggest that it is feasible to optimize fabrication parameters to obtain appropriate cell sizes and lifetimes that satisfy the application requirements for various organs. This study provides the basis for precise scaffold design and quantitative analysis of PLA foams in tissue engineering applications.

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