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中文摘要：
目的探讨CD4^＋ CD25^high调节性T细胞在幼年特发性关节炎（JIA）发病机制中的作用。方法利用流式细胞术检测JIA患儿外周血和关节液中T细胞表面CD4和CD25表达,并利用胞内染色技术检测细胞内转录因子FoxP3。同时检测年龄和性别相匹配的7例健康体检儿童外周血作为正常对照。结果JIA患儿关节液中高表达CD25的CD4^＋ T细胞（CD4^＋CD25^high）明显多于JIA和正常人外周血,而JIA外周血中数量又少于正常人外周血。CD4^＋ CD25^highT细胞表达高水平的FoxP3。结论JIA患儿关节局部天然调节性T细胞增多,可能与其发病机制有关。
英文摘要：
Objective To investigate the potential role of CD4 ^＋ CD25 ^high in the generation of juvenile idiopathic arthritis （JIA）. Methods Expression of CD4 and CD25 on T ceils in peripheral blood and synovial fluid were examined by flow cytometry, and the FoxP3 expression was detected through intracellular staining. Peripheral blood from 7 healthy children matched in age and gender served as normal control. Resuits Compared with normal control, there were increased number of CD4^＋ CD25 ^high T cell in JIA synovial fluid which expressed high level FoxP3, but decreased number in peripheral blood. Conclusion Accumulation of natural regulatory T cells in local tissue of JIA may contribute to the pathological process of such disease.
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