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钽棒置入与腓骨支撑修复早期股骨头坏死
  • ISSN号:2095-4344
  • 期刊名称:《中国组织工程研究》
  • 时间:0
  • 分类:R38[医药卫生—医学寄生虫学;医药卫生—基础医学]
  • 作者机构:[1]广西中医药大学,广西壮族自治区南宁市530001, [2]广西中医药大学第一附属医院骨三科,广西壮族自治区南宁市530023, [3]广西中医药大学附属瑞康医院骨科,广西壮族自治区南宁市530011, [4]广州中医药大学第一附属医院关节三骨科,广东省广州市510000
  • 相关基金:国家自然科学基金项目(81360551)广西科学研究与技术开发计划项目(桂科攻1140003B-57);广西医疗卫生重点科研课题(重2011053)
中文摘要:

背景:腓骨支撑以及钽棒置入是治疗早期股骨头坏死常见的方法,可有效延缓甚至逆转股骨头坏死进展,但二者术后股骨头力学支撑与疗效对比需要进一步探讨。目的:比较腓骨支撑、钽棒置入修复早期股骨头坏死的临床效果。方法:ARCOⅠ期、Ⅱ期股骨头坏死患者共58例81髋,按治疗方案分为2组,其中腓骨支撑组30例41髋采用腓骨支撑术治疗,钽棒置入组28例40髋采用钽棒置入术治疗。2组术后均获得2年以上随访,比较治疗前、后髋关节Harris评分,分别以股骨头塌陷和股骨头塌陷〉4 mm为观察截点,比较不同ARCO分期2组股骨头生存率。结果与结论:(1)2组术后Harris评分均较术前明显提高,差异有显著性意义(P〈0.05);(2)以术后股骨头塌陷为观察截点的Kaplan-Meier生存曲线比较显示,髋关节总生存率腓骨支撑组为83%,钽棒置入组为65%;经log-rank(Mantel-Cox)检验,2组ⅡC期髋关节生存率差异有显著性意义(P=0.043 1);(3)以术后股骨头塌陷〉4 mm为股骨头生存终点Kaplan-Meier生存曲线比较显示,髋关节总生存率腓骨支撑组为95%,钽棒置入组为83%;经log-rank(Mantel-Cox)检验,2组ⅡC期髋关节生存率差异有显著性意义(P=0.041 8);(4)综上,腓骨支撑术、钽棒置入术治疗早期股骨头坏死均可有效改善髋关节功能;ARCOⅡC期患者腓骨支撑治疗的髋关节生存率优于钽棒置入。

英文摘要:

BACKGROUND: Fibular fixation and tantalum rod implantation are two commonly used methods for the treatment of early osteonecrosis of the femoral head (ONFH), both of which can effectively delay or even reverse the progress of ONFH. However, further comparative evaluation on their mechanical properties and therapeutic efficacy is required. OBJECTIVE: To compare the clinical efficacy of fibular fixation and tantalum rod implantation on ONFH at early stage. METHODS: Fifty-eight patients (81 hips) suffered from ONFH with ARCO stage 1 and stage 2, and underwent fibular fixation (30 cases, 41 hips) or tantalum rod implantation (28 cases, 40 hips). Postoperatively, both groups were followed up for over 2 years. The Harris scores of the hip were compared between two groups before and after treatment. With femoral head collapse and the collapse distance 〉 4 mm as observation points, the survival rate of the femoral head was compared between two groups. RESULTS AND CONCLUSION: The postoperative Harris scores of the two groups were significantly improved than before (P 〈 0.05). With the appearance of femoral head collapse as the observation point, the Kaplan-Meier survival curve showed that the overall survival rate of the hip was 83% in the fibular fixation group and 65% in the tantalum rod implantation group. After examined by log-rank (Mantel-Cox), there was a significant difference in the survival rate of the hip at Stage IIC between two groups (P=0.043 1). With 〉 4 mm collapse as the observation point, the Kaplan-Meier survival curve showed that overall survival rate of the hip was 95% in the fibular fixation group and 83% in the tantalum rod implantation group. After examined by log-rank (Mantel-Cox), there was a significant difference in the survival rate of the hip at Stage IIC between two groups (P=0.041 8). To conclude, both fibular fixation and tantalum rods implantation applied to ONFH at early stage can effectively improve the hip function, and the survival rate

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期刊信息
  • 《中国组织工程研究》
  • 北大核心期刊(2014版)
  • 主管单位:中华人民共和国卫生和计划生育委员会
  • 主办单位:中国康复医学会 《中国组织工程研究》杂志社
  • 主编:唐佩福
  • 地址:沈阳浑南新区10002邮政信箱
  • 邮编:110180
  • 邮箱:crter3377@163.com
  • 电话:024-31416864
  • 国际标准刊号:ISSN:2095-4344
  • 国内统一刊号:ISSN:21-1581/R
  • 邮发代号:8-584
  • 获奖情况:
  • 2001“百种中国杰出学术期刊,卫生部首届医药卫生优秀获奖期刊,北方优秀期刊,辽宁省一级期刊,第三、四届沈阳市优秀期刊一等奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,荷兰医学文摘,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2014版)
  • 被引量:16688