中文摘要：

目的：建立基于脂质体毛细管电泳（LCE）的一种快速测定脂水分配系数（P）的方法,将其测定结果与摇瓶法测得值进行比较,验证方法的可靠性和适用性。方法：根据已知P值的标准化合物在脂质体中的迁移时间tm,以其logP的非线性关系,再通过待测药物的tlip,求得药物的脂水分配系数。结果：不同批次的脂质体测得的药物的logP值的重现性较好,RSD为5.7%,用LCE法测得的6种药物的logP值与文献值吻合,平均差值为0.30。结论：LCE法简单、快速,重现性较好,从已测定的6种药物的logP值来看,准确度较高,为药物脂水分配系数的测定提供了一种新的方法。

英文摘要：

Objective：To measure lipid-water partition coefficients（P）of pharmaceuticals by LCE method.And its logarithm（logP）values of six pharmaceuticals determined by this LCE method were compared with literature values.Method：The migration time of liposome phase（tlip）was obtained by non-linearity fitting with logP values from literature and measured migration time（tm）of a series of standard compounds,a calibration curve for estimating logP of pharmaceuticals was thus obtained.Results：The logP values of 3 pharmaceuticals measured by LCE method using the different liposome were close to the literatures,and the average RSD was 5.7%.The logP values of 6 pharmaceuticals measured by LCE method were close to those determined by shake-flask method,and the average error between values from two methods was 0.30.Conclusions：This method is simple,rapid,reproducible and reliable,which can be useful to estimate lipid-water partition coefficients of pharmaceuticals.