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中文摘要：
研究了不同的Lewis酸催化剂、温度、微波等条件下，4-（4．甲氧苯基）-1-苯基-3-三甲基硅氧基-2-氮杂-1，3-丁二烯（2-ABDE）和亲二烯体环己酮发生杂Diels-Alder反应生成[4＋2]的六元环合产物嗯嗪酮衍生物，伴随的2-ABDE的[2＋2]单分子环合，生成单环β-内酰胺衍生物．结果表明：在低温条件下如（-78℃）[4＋2]反应占主导；而在高温条件下（如135℃）仅进行[2＋2]反应．微波加热方式可显著提高[2＋2]反应的速率和产率．不同的Lewis酸催化剂对[2＋2]反应和[4＋2]反应的催化效率不同．Lewis酸的酸性强弱、软硬对2-ABDE的[2＋2]反应的催化能力起决定性作用．
英文摘要：
During the hetero Diels-Alder reaction （HAD） between 4-（4-methoxyphenyl）-1-phenyl-3- （trimethylsilyloxy）-2-aza-butadiene （2-ABDE） and hexanone, a unimolecular [2＋2] cyclization of 2-ABDE forming a four-membered monocyclic β-lactam took place. The reaction parameters such as Lewis acid catalysts, temperature and microwave irradiation on the HDA and [2＋2] reactions have been thoroughly studied. The results show that the competition between the [2 ＋2] and [4 ＋2] reactions is largely dependent of temperature. At low temperature as -78 ℃, the product of [4＋2] reaction predominated, while at high temperature as 135 ℃, the product of [2＋2] reaction predominated. Microwave irradiation improved the yield of the [2＋2] reaction significantly. It was also found that the strength and the hardness of the Lewis acid affected the catalytic ability for the [2 ＋ 2] reaction of 2-azabutadiene.
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