中文摘要：

粪便基因甲基化作为一种新的、敏感度较高、特异性中等的无创性结直肠肿瘤标志物,能根据其阳性结果对疑似病例进行进一步检测,可作为筛查诊断结直肠肿瘤的一种重要的辅助手段。目前已有较多研究报道检测粪便中基因异常甲基化对于早期结直肠癌（colorectal cancer,CRC）筛查有较高的敏感性和特异性,但尚无任何一种甲基化基因真正地应用于临床实践。本文对目前结直肠癌早期粪便DNA甲基化检测的国内外相关研究成果进行综述,总结粪便甲基化检测的潜在临床价值。

英文摘要：

Fecal DNA methylation,as a new,high sensitivity and specificity,and non-invasive colorectal tumor markers,can be used as screening diagnosis of colorectal cancer（ CRC）.There are growing reports about testing aberrant methylation in feces for early CRC screening,but there is no any of methylation gene really applied in clinical practice.This article reviews the relevant articles published between 2000 and 2014 and summarizes its potential clinical value of fecal DNA methylation detection.