中文摘要：

目的：探讨干扰素调节因子2（interferon regulatory factor 2,IRF2）在人食管鳞癌组织中的表达及其与病理特征和预后的关系。方法：采用免疫组化SP法检测69例食管鳞癌组织和45例癌旁组织的IRF2表达,分析其与临床病理特征及预后之间的关系。结果：IRF2在食管鳞癌组织中的表达明显高于癌旁组织,并与肿瘤分化程度、淋巴转移及TNM分期明显相关。单因素生存分析发现IRF2表达、分化程度、淋巴转移与患者的无进展生存显著相关,多因素分析则证实IRF2是预后的独立风险因子。结论：IRF2在食管鳞癌中高表达,并且是不良预后的独立风险因子,提示其可能发挥癌基因的功能。

英文摘要：

Objective： To study the expression and clinical significance of interferon regulatory factor 2（ IRF2） in esophageal squamous cell carcinoma（ ESCC）. Methods： Immunohistochemistry（ SP assay） was used to detect the expression of IRF2 in 69 patients with ESCC compared with non- tumor adjacent tissues（ NAT,n = 45）. The relationship between its expression and clinical features were analyzed. Results： The expression level of IRF2 in ESCC was significantly higher than that of NAT. And over- expression of IRF2 was correlated with tumor differentiation,lymph node metastasis and TNM stage. Over- expression of IRF2,tumor differentiation and lymph node metastasis were significantly associated with shorter progression free survival in univariate analysis. Multivariate analyses indicated that high IRF2 expression might be a poor prognostic factor. Conclusion： IRF2 was over- expression and a poor prognostic factor in ESCC,implicating it might play as a oncogene in the ESCC development.