中文摘要：

长期的肝炎 B 病毒(CHB ) 当前与基于干扰素的任何一个或 nucleot 被对待基于 ide 的抗病毒的治疗。然而，有 pegylated 干扰素 alpha 的治疗在仅仅大约 30% 病人导致持久的抗病毒的回答并且与副作用被联系。接受 nucleot ide 类似物治疗的大多数病人不建立感染的长期的、持久的控制并且在治疗的停止以后有反弹的 viremia。因此，新奇治疗策略是必要的完成有势力的正式就职和能维持病毒的复制的长期的控制的病人的持久的抗病毒的有免疫力的回答。HBV 搬运人的治疗学的种痘是为肝炎 B 的控制的有希望的策略。这里，作者考察新治疗学的种痘策略对待以后可以为耐心的治疗被介绍的长期的肝炎 B。

英文摘要：

Chronic hepatitis B virus （CHB） is currently treated with either interferon-based or nucleot（s）idebased antiviral therapies.However,treatment with pegylated interferon alpha results in a durable antiviral response in only about 30％ patients and is associated with side effects.Most patients receiving nucleot（s）ide analogue treatment do not establish long-term,durable control of infection and have rebounding viremia after cessation of therapy.Thus,novel therapy strategies are necessary to achieve the induction of potent and durable antiviral immune responses of the patients which can maintain long-term control of viral replication.Therapeutic vaccination of HBV carriers is a promising strategy for the control of hepatitis B.Here the authors review new therapeutic vaccination strategies to treat chronic hepatitis B which may be introduced for patient treatment in the future.