中文摘要：

目的探讨Th17细胞及其相关细胞因子IL-17、TGF—β1、IL-22在银屑病发病过程中的变化及窄谱中波紫外线（NB—UVB）的干预效果。方法选取寻常型银屑病患者30例为观察组，采用NB—UVB照射治疗；对比治疗前后的银屑病面积和严重指数（PASI）评分及瘙痒程度（VAS）评分；并选取同期健康志愿者30例为对照组，进行同步研究，所有研究对象均抽取空腹静脉血，以流式细胞术检测Th17细胞计数，以ELISA试剂盒检测IL-17、TGF—β1、IL-22的血清含量。结果治疗后，患者的PASI评分和VAS评分均有显著降低（t=7．889，3．622；P=0．000，0．017）；PASI改善指数和VAS改善指数分别为40．8％、36．7％。治疗前，观察组患者的外周血Thl7细胞计数与血清IL-17、TGF-β1、IL-22水平均显著高于对照组（t=41．071，11．397，12．568，7．083；P：0．000），且治疗后显著降低（t=20．942，2．436，6．536，3．138；P=0．000，0．038，0．000，0．023）。结论Thl7细胞功能亢进可能是银屑病的重要发病机制之一，NB—UVB可能通过下调患者Th17细胞比例，减少其相关细胞因子分泌水平而发挥治疗作用。

英文摘要：

Objective To explore the exchanges of Thl7 cell count and its cytokines＇ level of IL-17,TGF-β1 and IL-22 in the onset and NB-UVB remedy of psoriasis. Methods Both patients with psoriasis （ Group Observation,n = 30） and homochronous healthy volunteers （ Group Control, n = 30） were selected to do contractive study. All patients were treated with NB-UVB,which PASI score and VAS score were assessed before and ＇after the treatment. At the same time, the pe- ripheral blood of all subjects were extracted, and Thl7 cell count was detected with flow cytometry, while the serum levels of IL-17 ,TGF-β1 and IL-22 were detected with ELISA kits. Results The PASI score and VAS score of the patients were all decreased significantly after treatment（t =7. 889,3. 622;P =0.000,0. 017） ;and the improve rate of PASI and VAS were 40.8% and 36.7% , respectively. At the same time,the Thl7 cell count and IL-17, TGF-β1, IL-22 levels of Group Observation before treatment were all significantly higher than those of Group Control （ t = 41. 071,11. 397,12. 568, 7. 083 ;P = 0. 000 ）, which all decreased significantly ＂after treatment （ t = 20. 942,2. 436,6. 536,3. 138 ; P = 0. 000, 0.038,0. 000,0. 023 ）. Conclusion Our research results showed that the hyperfunction of Thl7 cells may be one of the pathogenesis of psoriasis ,and NB-UVB may play a role of treatment through regulating down Thl7 cell proportion and re- strain the secretion of its cytokines.