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二乙酰姜黄素金属（铜,铂）配合物的合成及其与ctDNA的键合作用
  • ISSN号：1005-1511
  • 期刊名称：《合成化学》
  • 时间：0
  • 分类：O627[理学—有机化学;理学—化学] R914.5[医药卫生—药物化学;医药卫生—药学]
  • 作者机构：[1]安徽中医学院药学院,安徽合肥230031
  • 相关基金：国家自然科学基金资助项目（21071001）; 安徽省自然科学基金资助项目（1208085MH273）; 安徽省级高校自然科学研究重点项目（KJ2010A222）; 现代中药安徽省工程技术研究中心项目; 安徽中医学院自然科学研究重点项目（2011zr0005A）
作者： 姜波[1], 魏冬[1], 范九良[1], 汪佳凤[1], 周双生[1]
关键词： 二乙酰姜黄素, 金属配合物, 合成, 与DNA作用, diacetyl curcumin, metal complexes, synthesis, intereaction with ctDNA
中文摘要：

以姜黄素为原料,合成了二乙酰姜黄素（H2L）及其铜（Ⅱ）和铂（Ⅱ）配合物（CuL2和PtL2）,其结构经1H NMR,IR,MS和元素分析确认。采用UV-Vis测定法和循环伏安法研究了CuL2和PtL2与ctDNA的相互作用。结果表明,CuL2和PtL2与ctDNA的作用属嵌插作用模式。

英文摘要：

Diacetyl Curcumin（H2L） and its metal[copper（Ⅱ）,platinum（Ⅱ）] complex,CuL2 and PtL2,were synthesized from curcumin.The structures were characterized by 1H NMR,IR,MS and elemental analysis.The interactions of the CuL2 and PtL2 with ctDNA were studied by UV-Vis test method and cyclic voltammetry method.The results showed that interactions model of CuL2 and PtL2 with ctDNA was presumably intercalative model.

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期刊信息
  • 《合成化学》
  • 中国科技核心期刊
  • 主管单位:四川省科学技术协会
  • 主办单位:四川省化学化工学会 中国科学院成都有机化学有限公司
  • 主编：熊成东
  • 地址：成都市武侯区人民南路四段9号
  • 邮编：610041
  • 邮箱：hchx@cioc.ac.cn
  • 电话：028-85255007
  • 国际标准刊号：ISSN：1005-1511
  • 国内统一刊号：ISSN：51-1427/O6
  • 邮发代号:62-196
  • 获奖情况:
  • 1998年上C.A千名表（803位）,1999年入选《中国科学引文数据库》来源期刊,1999-2002年作为《中国学术期刊综合评价数据库》...
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,中国中国科技核心期刊,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,英国英国皇家化学学会文摘
  • 被引量:7579