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中文摘要：
以取代苯甲醛、二硫化碳和氨基硫脲等为原料，合成了7个未见文献报道的噻二唑含硫Schiff碱类衍生物1a～1g。目标化合物的结构经IR、。HNMR、MS和元素分析表征；并用单晶x射线衍射测定了化合物1c的结构。采用MTT法考察了目标物体外对人肺癌细胞（A549）和人乳腺瘤细胞（MCF-7）的抗肿瘤活性，结果表明，所有目标物均具有一定的抗肿瘤作用，1c的活性优于氟尿嘧啶。
英文摘要：
The novel thiadiazole Schiff bases containing sulfur （la~lg） were easily and efficiently synthesized by multi-step reactions starting from substituted benzaldehydes, carbon disulfide and thiosemicarbazide and so on. The title compounds were characterized by IR, IH NMR, MS and elemental analyses. Their in vitro antitumor activities against A549 and MCF-7 cell lines were evaluated by MTT assay. The results showed that the compounds displayed potential antitumor activities against the tested cancer cell lines, especially. Compound le exhibited better inhibitory potency than 5-fluorouracil against all tested cell lines.
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