中文摘要：

目的评估中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和C反应蛋白（CRP）对急性胰腺炎（AP）患者发生急性肾损伤（AKI）的预测价值，为AKI早期诊断提供有价值的参考。方法选取深圳市第六人民医院2013年1月～2015年12月住院的新发AP患者125例，分为轻型AP组（MAP组）、重型AP组（SAP组），依据是否发生AKI又分为AKI亚组和非AKI亚组，采用ELISA法测定尿NGAL水平及绘制受试者工作曲线反应比较CRP预测AKI的价值。结果所有MAP患者均无AKI发生，47例SAP患者中有30例发生AKI（占63．8％）；入院后2h内测MAP组及SAP组患者尿NGAL水平相近，差异无统计学意义（P〉0．05）。此后尿NGAL逐渐升高，峰值出现在入院后12h，且SAP组AM亚组NGAL明显高于非AM亚组和MAP组，差异有统计学意义（P〈0．05）；NGAL预测AKI发生的ROC曲线下面积（AUC）〉CRP，差异有统计学意义（P〈0．05）。结论NGAL对SAP患者并发AKI具有早期诊断价值，早期诊断价值高于CRP。

英文摘要：

Objective To evaluate the prognostic value of neutrophil gelatinase-associated lipocalin （NGAL） and C reactive protein （CRP） in acute pancreatitis patients with acute kidney injury （AKI）, and to provide valuable reference for early diagnosis of AKI. Methods 125 cases of newly diagnosed AP patients hospitalized in Shenzhen Sixth People＇s Hospital from January 2013 to December 2015 were se!ected and divided into light AP group （group MAP） and severe AP group （group SAP）. According to whether the occurrence of AKI, they were also divided into AKI subgroup and non AKI subgroup. ELISA was used to determine urinary NGAL level and draw the receiver operating curve. The value of CRP in predicting AKI was compared. Results No AKI occurred in all MAP patients. Among the 47 cases of SAP patients, there were 30 patients with AKI （accounting for 63.8%）. Within 2h after admission, the level of NGAL in urine of group MAP and group SAP were similar, and there was no significant difference （P 〉 0.05）. The urine NGAL increased gradually, and the peak vglue appeared at 12h after admission. NGAL in AKI subgroup of SAP was significantly higher than that in non AKI s~bgroup of MAP group, the difference was statistically significant （P 〈 0.05）. the area under the ROC curve, that was NGAL predicted the happeness of AKI, was （AUC） 〉 CRP, the difference was statistically significant （P 〈 0.05）. Conclusion NGAL has early diagnosis value of patients with SAP complicated with AKI. Its early diagnosis value is higher than CRP.