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长非编码RNA的功能研究

ISSN号：1001-1978
期刊名称：《中国药理学通报》
时间：0
分类：R05[医药卫生] R339.38[医药卫生—人体生理学;医药卫生—基础医学]
作者机构：[1]南昌大学医学院生理学教研室,江西南昌330006
相关基金：国家自然科学基金资助课题（No81200853,81171184,31060139）

关键词：长非编码RNA, 衰老, 老化相关疾病, 转录组分析, 研究方法, 生物信息学

中文摘要：

长非编码RNA（long noncoding RNAs，lncRNAs）是指长度大于200个核苷酸的RNA分子。近年来的研究表明，lncRNAs具有多种重要的生物学功能。随着现代生物技术的发展，lncRNAs转录本的预测及发现已经比较容易，然而不同于蛋白质编码基因序列所具有的指示功能，lncRNAs序列信息目前不提供功能信息的预测。因此，如何解码lncR-NAs的功能已逐渐成为基因组研究中的热点问题。我们将对探测lncRNAs功能的研究方法进行综述。

英文摘要：

Long noncoding RNAs ( lncRNAs ) are transcribed RNA molecules greater than 200 nucleotides in length. In recent years, studies have shown that lncRNAs have many important bi-ological functions. With the development of modern biological technology, lncRNAs transcripts can be easily detected and pre-dicted. However, unlike protein-coding genes whose sequence motifs usually have indicative function, lncRNA sequence infor-mation is currently uninformative for function prediction. Thus, how to decode the function of lncRNAs has gradually become a hot issue in genome research. The paper summarizes the studies regarding the methods to probe the function of lncRNAs.

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