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中文摘要：
趋化因子是一组能够趋化细胞定向移动的小分子细胞因子,参与白细胞迁移的调控,在炎症中诱导性表达,与炎症过程密切相关,最初的研究主要局限于免疫系统。近几年来研究发现,趋化因子不仅参与糖尿病的炎症过程,而且在糖尿病并发症的发生发展中发挥重要的调节作用。该文主要针对趋化因子5及其受体CCR5在糖尿病并发症中的作用及相关机制的研究予以综述,以便深入理解趋化因子与糖尿病的关系,为进一步的研究提供帮助。
英文摘要：
Chemokines are a large family of small cytokines that control cell trafficking.Chemokines and their receptors are intimately involved in the process of inflammatory and inducibly expression.Therefore,the primal studies were confined to the immune system.However,recent intriguing findings reveal that chemokines are not only involved in the inflammatory process of diabetes,but also play the important regulative role in the genesis and development of diabetic complication.This review summarizes the recent advances in the role of chemokine ligand 5（CCL5） and its receptor chemokine receptor 5（CCR5） in diabetic complication and their mechanisms concerned,which will help further understand the relationship between chemokines and diabetes and will provide evidence for further research.
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