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中文摘要：
P2X7受体为胞外ATP激活的非选择性阳离子通道，并能触发白介素-1β、白介素-18、肿瘤坏死因子和一氧化氮等前炎性物质的释放。临床研究表明，P2X7受体参与炎症和疼痛机制，调节P2X7受体功能的化合物，具有潜在的新抗炎药物的作用。因此，P2X7受体在炎症和疼痛中发挥重要的生理作用及潜在的临床应用，成为疼痛治疗的药物作用新靶点。
英文摘要：
The P2X7 receptor （P2X7 R）is a nonselective cation channel activated by extracellular ATP,and it may trigger the se-cretion of several proinflammatory substances,such as IL-1β, IL-18,TNF-α,and nitric oxide.Several preclinical studies have demonstrated that this receptor participates in inflammation and pain mechanisms,and compounds that modulate the function of this receptor show potential as new anti-inflammatory medicines.＆amp;nbsp;Therefore,P2X7 receptors play particularly important physiologi-cal roles and have potential clinical application in inflammation and pain,which proves it a therapeutic target for pain manage-ment.
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