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中文摘要：
在人类基因组中蛋白质编码基因小于2％，基因序列转录后主要形成由非编码RNA（noncodingRNA，ncRNA）组成巨大的分子网络，它们在真核生物调节细胞活动中发挥核心作用。参与基因调控的非编码RNA主要分为短非编码RNA和长非编码RNA（10ngnoncodingRNA，IncRNAs）两类，大部分非编码RNA研究都集中在短ncRNA。但研究表明，长非编码RNA可作为基因调控网络中的主要参与者促进基因的转录调控，与各种人类疾病的机制密切相关。
英文摘要：
Less than 2% of genes in human genome are protein- coding genes, and gene sequence is mainly transcribed into huge molecular network of non-coding RNAs （ncRNAs） , which plays a central role in adjusting cellular activity in eukaryotes. NeR- NAs participating in gene regulation are mainly divided into two classes： short ncRNAs and long ncRNAs （lncRNAs）. Most studies of ncRNAs have been focused on short ncRNA. Howev-er, studies have shown that lncRNAs, as the major participants of gene regulatory network, contribute to the transcriptional regu- lation of gene and are closely related to the mechanisms of vari- ous human diseases.
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