RNA干扰(RNAi)技术是由人工导入的双链RNA介导的特异性的转录后基因沉默技术。近年RNAi技术已大量应用于裸鼠移植瘤中,RNAi裸鼠体内实验,通过敲低肿瘤的凋亡抑制基因、促增生基因、肿瘤细胞浸润转移基因的表达,达到抑制肿瘤的效果。同时,RNAi在裸鼠移植瘤内可作为肿瘤放化疗的辅助手段。
RNA interference (RNAi) is a post-transcriptional suppression method of introduction of double-stranded RNA molecules by artificially induced. Recently RNAi has been widely used in xenografted tumors of nude mice in vivo. In order to inhibit the growth of tumor, some genes related with tumor such as anti-apoptosis gene, proliferation promoting gene, metastasis-associated gene are depressed via RNAi. Additionally, in the nude mice test, RNAi is utilized as assisting methed of radiotherapy and chemotherapy of human tumors.