中文摘要：

目的：研究新疆大枣抗肿瘤作用。方法：ICR小鼠随机分为模型组、环磷酰胺（CTX）组、25%大枣汁组、50%大枣汁组、100%大枣汁组、CTX＋100%大枣汁组,每组10只。右前肢腋窝皮下接种S180小鼠肉瘤细胞,24 h后连续给药（大枣汁灌胃,20 mL.kg-1.d-1,CTX腹腔注射,50 mg.kg-1.d-1）14 d后,测定瘤重、抑瘤率、胸腺和脾脏脏器指数,外周血象、血清白介素-2（IL-2）和肿瘤坏死因子-α（TNF-α）、生存时间和生命延长率。结果：与模型组比较,CTX组、100%大枣汁组和CTX＋100%大枣汁组瘤重、胸腺、脾脏指数明显降低;与CTX组比较,50%大枣汁、100%大枣汁组和CTX＋100%大枣汁组胸腺、脾脏指数明显升高;与模型组比较,CTX组白细胞数（WBC）、血小板计数（PLT）明显降低,100%大枣汁组RBC与WBC明显升高;与CTX组比较,50%大枣汁组、100%大枣汁组和CTX＋100%大枣汁组WBC与PLT明显升高;与模型组比较,CTX组的IL-2和TNF-α水平明显降低;与CTX组比较,50%大枣汁组、100%大枣汁组和CTX＋100%大枣汁组IL-2和TNF-α明显升高;与模型组比较,50%大枣汁组、100%大枣汁组和CTX＋100%大枣汁组组生存时间明显延长;与CTX组相比较,CTX＋100%大枣汁组生存时间明显延长。结论：新疆大枣对荷瘤小鼠体内肿瘤细胞的增殖有明显的抑制作用。

英文摘要：

Objective：To study the anti-cancer effection of Xinjiang Jujube.Method： ICR mice were randomly divided into model group,cyclophosphamide（CTX） group,25% jujube juice group,50% jujube juice group,100% jujube juice group,CTX＋100% jujube juice group（n=10）.Right forelimb axillary subcutaneous inoculation of S180 mouse sarcoma cells 24 h after administration（jujube juice orally 20 mL·kg-1·d-1,CTX intraperitoneal injection of 50 mg·kg-1·d-1） 14 d after the determination of tumor weight inhibition rate,index of thymus and spleen,organs,peripheral blood,serum interleukin-2（IL-2） and tumor necrosis factor-alpha（TNF-α）,the survival time and life prolongation rate.Result：Compared with model group,the CTX group,100% jujube juice group and the CTX＋100% jujube juice group tumor weight,thymus,spleen index was significantly reduced;compared with the CTX group,50% jujube juice group,100% jujube juice group and the CTX＋100% jujube juice group,thymus,spleen index was significantly increased;compared with model group,White blood cell count（WBC）,platelet count（PLT）,the CTX group decreased significantly,100% jujube juice group,RBC and WBC significantly increased;compared with the CTX group,50%group of jujube juice,jujube juice group of 100% and CTX＋100% jujube juice group,WBC and PLT was significantly increased;compared with model group,the CTX group of IL-2 and TNF-α levels decreased significantly;compared with the CTX group.50% jujube juice group,100% jujube juice group and CTX＋100% jujube juice group IL-2 and TNF-α significantly increased;compared with model group,50% jujube juice group,100% jujube juice group and CTX＋100% jujube juice group significantly prolonged the survival time;compared with the CTX group,CTX＋100% jujube juice group significantly prolonged survival time.Conclusion： Xinjiang jujube can significantly inhibit the growth of tumor cells in the mice.