中文摘要：

研究了解新疆维吾尔族冠心病患者血管紧张素转换酶（ACE）基因、内皮型一氧化氮合酶（eNOS）基因、凝血因子Ⅶ（FⅦ）基因、细胞黏附分子-1（ICAM-1）基因等的多态性变化。入选已确诊的维吾尔族冠心病患者124例和维吾尔族健康志愿者50例,采用聚合酶链式反应-限制性片段多态性（PCR-RFLP）方法,分别检测及比较维吾尔族冠心病患者及健康志愿者4种基因型及其等位基因频率。结果显示,冠心病组与健康对照组相比,ACE基因、FVII基因、ICAM-1基因在基因型及等位基因频率方面均无显著性差异（P〉0.05）;冠心病组在eNOS基因型和等位基因频率分布两方面与健康对照组比较,均有显著性差异（P〈0.05）。结论为ACE基因、FⅦ基因、ICAM-1基因多态性与新疆维吾尔族冠心病患者的关系不明显,而eNOS基因多态性与维吾尔族冠心病患者有相关性。

英文摘要：

The gene polymorphism of Angiotensin-Converting Enzyme （ACE） gene, Nitric Oxide Synthase （eNOS） gene, coagulation Factor Ⅶ （FⅦ） gene and Intercellular Cell Adhesion Molecules-1 （ICAM-1） in Uighur patients with Coronary Heart Disease （CHD） in Xinjiang are studied in this paper. The four types of genes related to CHD are compared to each other by using polymerized chain reaction-restriction fragment length polymorphism （PCR-RFLP） in 124 cases of CHD Uighur patients and 50 healthy subjects as verified by diagnosis. The results show that there are no significant differences in genotype distribution and allele frequencies of A CE gene, FⅦ gene, ICAM-Ⅰ gene in Uighur patients with CHD when compared to healthy subjects （P〉0.05）. There are significant differences in genotype distribution and allele frequencies of eNOS gene in Uighur patients with CHD when compared to healthy subjects （P〈0.05）. There is no correlation in genotype distribution and allele frequencies of ACE gene, FⅦ gene, ICAM-1 gene in Uighur patients with CHD in Xinjiang. Significant correlation is discovered in genotype distribution and allele frequencies of eNOS gene in Uighur patients with CHD in Xinjiang.