中文摘要：

目的探讨宁夏地区致泻性大肠杆菌（Diarrheagenic E，Coli scherichia，DEC）菌群分布、药物敏感性情况，为腹泻病防控提供依据。方法2010—2011年共收集宁夏医科大学总医院、银川市第二人民医院、中卫市医院、青铜峡市医院门诊及住院腹泻患者新鲜大便1520份，接种于买康凯（MaC）培养基，挑选麦康凯琼脂平板上玫瑰红色光滑型菌落，转种TSA平板，37℃培养24h，采用聚合酶链反应（PCR）进一步做菌株鉴定及分型；细菌药敏采用Kirby—Bauer法。结果1520例腹泻患者共检出98株DEC，检出率为6．45％，其中主要为PEC检出53株。占分离大肠菌株的54．08％。药敏试验结果表明，DEC对常用抗生素均产生较高的耐药性，对氨苄西林、阿莫西林和复方磺胺甲恶唑的耐药性最为严重，达到100％，庆大霉素、氯霉素和头孢噻肟的敏感性较高。结论宁夏地区致腹泻病原主要为DEC，且对常用抗生素具有较高的耐药性，应引起高度重视。

英文摘要：

Objective To discuss the distribution and drug sensitivity of diarrheagenic E coliflora in Ningxia so as to provide the ba-sis for diarrhea prevention and control. Methods The fresh stool of 1 520 diarrhea cases was obtained from General Hospital of Ningxia Medi-cal University, the Second People＇s Hospital of Yinchuan, Zhongwei People＇s Hospital and Qingtongxia People＇s Hospital, and then inoculated the stool on the Mac medium and sorted out the rose-bengal smooth flora on the Mac agar plate, adapted on TSA plate, raised in 37℃ for 24h. Strain identification and classification were made by using PCR. Antimicrobial susceptibility used the Kirby-Bauer method. Results 98 diarrheagenic E were found in 1520 patients. Coli with a positive rate was 6. 45%, EPEC was higher than other coli. gesults showed that drugs with higher resistance rate were commonly used antibiotics. The identification of strains showed that it was pathogenic E coli type. The drug resistance rates of AMP and AML OXA were more than 99%, and there was higher sensitivity to GM, C and CTX. Conclusion The EPEC of diarrheagenic coli is popular in Ningxia and there is a high resistance to commonly use antibiotics.