中文摘要：

目的探讨正压呼吸机在轻度认知功能障碍伴睡眠呼吸暂停综合征临床治疗中的应用效果。方法选择我院2010年6月～2017年1月收治的100例存在轻度认知功能障碍并伴发睡眠呼吸暂停综合征患者，随机分为治疗组及对照组，每组50例。对照组予常规治疗，治疗组在对照组基础上行正压呼吸机治疗。观察两组3周、6周、9周、12周的MOCA评分及血压、血糖、血脂情况，并进行统计学分析。结果治疗后3周、6周、9周、12周两组的MOCA评分与本组治疗前进行比较均出现显著上升，且治疗后组间不同时间点评分均存在统计学差异，治疗组均显著高于对照组（P〈0．05）；经不同的治疗两组血压、血糖、血脂水平均明显下降，但治疗后12周治疗组的血压、血糖、血脂水平明显低于对照组（P〈0．05）。结论对轻度认知功能障碍合并睡眠呼吸暂停综合征患者在常规治疗的基础上联合实施正压呼吸机治疗效果显著。可以更好地改善患者的MOCA评分及血压、血糖、血脂情况。

英文摘要：

Objective To investigate the application effect of positive pressure ventilator in the treatment of mild cogni- tive dysfunction complicated with sleep apnea syndrome. Methods 100 patients with mild cognitive dysfunction com- plicated with sleep apnea syndrome who were admitted to our hospital from June 2010 to January 2017 were included in this study. They were randomly divided into the treatment group and the control group, with 50 cases in each group. The control group was given conventional treatment, and the treatment group was given positive pressure ventilator on the basis of the control group. The MOCA scores, blood pressure, blood glucose and blood lipid were observed at 3 weeks, 6 weeks, 9 weeks and 12 weeks, and the statistical analysis was performed. Results The MOCA scores in the two groups at 3 weeks, 6 weeks, 9 weeks and 12 weeks after treatment were significantly higher than those before treat- ment, and the differences were statistically significant at different time points after treatment between two groups. The MOCA score in treatment group was significantly higher than the control group （P〈0.05）; after different treatments, the blood pressure, blood glucose, blood lipid levels of two groups were significantly decreased. However, the blood pres- sure, blood glucose and blood lipid levels in the treatment group 12 weeks after the treatment were significantly lower than those in the control group（P〈0.05）. Conclusion The patients with mild cognitive dysfunction complicated with sleep apnea syndrome on the basis of conventional treatment combined with the implementation of positive pressure ventilator has a significant curative effect, which can better improve the patients＂ MOCA score, blood pressure, blood sugar, blood lipid.