中文摘要：

alpha-latrotoxin (高山哈从黑寡妇的蜘蛛的 -LTX),a 神经毒素，在在到特定的膜 receptors.alpha-LTX~(N4C ) 的绑定以后的神经终端的触处前的原因泡版本是到为 latrotoxin (CIRL ) 的钙独立人士受体的有效工具绑定，它被用来阐明调停受体的信号小径的机制。在我们胰腺的贝它房间上的学习，我们发现了那座高山哈 -LTX 插入到血浆膜并且形成 stablenon 选择的阳离子隧道。，通过隧道的细胞外的 Ca~(2+) 的流入引起巨大的 Ca~(2+) 包含胰岛素的泡的依赖 exocytosis 高山哈有它以细胞外的二价的阳离子依赖者方法的受体 CIRL 的 -LTX~(N4C),binding，增加[Ca~(2+)] 细胞内部的钙店的 _iby 动员。

英文摘要：

α-latrotoxin （α-LTX）, a neurotoxin from black-widow spider, causes vesicles release in presynapse of nerve terminal after binding to specific membrane receptors, α-LTX^N4C is an effective tool binding to calcium independent receptor for latrotoxin （CIRL）, which is used to elucidate the mechanism of receptor-mediated signal pathway. In our study on the pancreatic β cells, we found that α-LTX inserts into the plasma membrane and forms stable non-selective cation channels. The influx of extracellular Ca^2＋ through the channels causes massive Ca^2＋-dependent exocytosis of insulin-containing vesicles, whereas, α-LTX^N4C, binding with its receptor CIRL in extracellular divalent cation-dependent way, increases [Ca^2＋]i by mobilization of the intracellular calcium stores.