中文摘要：

目的：考察艾片的体外黏膜渗透性及影响因素。方法：选择离体牛蛙腹皮为渗透模型,采用改良的Franz扩散池进行体外黏膜实验;GC测定艾片中龙脑的含量,研究接收液的不同pH值、温度、搅拌速度及药物浓度对艾片体外黏膜渗透的影响。结果：搅拌速度对艾片的渗透有一定的影响;而接收液的pH值、温度及药物浓度对艾片的渗透无影响。艾片黏膜渗透性良好,累积渗透率与时间符合一级吸收过程。结论：离体牛蛙腹皮可作为艾片的体外黏膜渗透性研究的实验模型。

英文摘要：

Objective： To study the in vitro mucosal factors that affect such permeability of borneol.Method： Bullfrog skin was selected as the permeation model,and the modifiled Franz diffusion was adopted to investigate the percutaneous adsorption in vitro.borneol as quantified by GC.Different of pH receiving solution and temperature,mixings peed and impacts of drug concentration on percutaneous adsorption invitro were systematically studied.Result： Percutaneous permeation of borneol was to some extent affected by mixings peed.Other fctors had no effect on the penetration of borneol.There existed a good percutaneous of borneol.And the relationship between the cumulative permeability rate and time was coincided with the first order kenetical process.Conclusion： Taken the in vitro abdominl skin of bullfrog as the permeation model,which were study on in vitro mucosal factors affecting mucosal permeability of borneol.