中文摘要：

geniposide (Ge ) 和自然龙脑(NB ) 是物质从繁体中文植物导出的 bioactive。在经由 intranasal 管理的老鼠的 Ge 的 pharmacokinetics 上的 NB 的效果被调查。在血浆的 Ge 的集中被反向阶段的高效的液体层析(HPLC ) 独自在 Ge (4 mg/kg ) 的 intranasal 管理以后决定并且与 NB 的不同剂量(0.08， 0.8，和 8 mg/kg ) 结合了。静脉内的管理作为一本参考书(Ge 的 4 mg/kg 和 NB 的 8 mg/kg ) 被给。与静脉内的管理相比， Ge 的绝对 bioavailability 通过管理与 NB 相结合的 intranasal 是 76.14% 。与 Ge 的 intranasal 管理相比独自一个， Ge 能很快被专心于与 NB 相结合的鼻音洞；在血浆的 Ge 的黄金时间变得更短(35 min 对 40 min ) ；山峰集中变得更高(1.324.25 g/ml 对 0.67 g/ml ) ；并且，与 NB 相结合的 Ge 的相对 bioavailability 是 90.3%237.8% 。当 NB 的剂量减少了，提高的效果被稀释。结果显示 NB 能在鼻音洞 dose-dependently 加速 Ge 的吸收。

英文摘要：

Both geniposide （Ge） and natural borneol （NB） are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography （HPLC） after intranasal administration of Ge （4 mg/kg） alone and combined with different doses （0.08, 0.8, and 8 mg/kg） of NB. The intravenous administration was given as a reference （4 mg/kg of Ge and 8 mg/kg of NB）. Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter （3-5 min vs. 40 min）; the peak concentration became higher （1.32-4.25 IJg/ml vs. 0.67 ug/ml）; and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.