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Comparative in vitro Study on Pure Metals （Fe, Mn, Mg, Zn and W） as Biodegradable Metals

ISSN号：1005-0302
期刊名称：《材料科学技术学报：英文版》
时间：0
分类：TG146.13[金属学及工艺—金属材料;一般工业技术—材料科学与工程;金属学及工艺—金属学] TQ323.8[化学工程—合成树脂塑料工业]
作者机构：[1]Department of Interventional Radiology and Vascular Surgery, Peking University Third Haspital, Beijing 100191, China, [2]Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
相关基金：This work was supported by the National Basic Research Program of China （973 Program）（Grant Nos. 2012CB619102 and 012CB619100）, National Science Fund for Distinguished Young Scholars （Grant No. 51225101 ）, National Natural Science Foundation of China （Grant Nos. 51431002 and 31170909）, the NSFC/RGCJoint Research Scheme （Grant No. 51361165101 ）, State Key Laboratory for Mechanical Behavior of Materials （Grant No. 20141615）, and Beijing Municipal Science and Technology Project （No. Z141100002814008）.

作者： J. Cheng[1], B. Liu[2], Y.H. Wu[1], Y.F. Zheng[1,2]

关键词：可生物降解, 锌合金, 商业用, 金属, 生物相容性, 血液相容性, 评价, 体外, Commercial Zn alloys Biodegradable metals Mechanical properties Corrosion behaviors Cytotoxicity Hemocompatibility

中文摘要：

在这个工作，三广泛地使用了商业 Zn 合金(ZA4-1， ZA4-3， ZA6-1 ) 被热挤出在 200 °C 购买并且准备。Zn 合金的微观结构，机械性质，腐蚀行为， biocompatibility 和 hemocompatibility 作为控制与纯 Zn 被学习。商业 Zn 合金与纯 Zn 相比表明了增加的力量和出色的延伸。加速的腐蚀率和一致腐蚀形态学由于在 Zn 矩阵和 -Al 阶段之间的流电的效果以商业 Zn 合金被观察。当所有样品的 50% 摘录显示了好 biocompatibility 时， ZA4-1 和 ZA6-1 合金的 100% 摘录显示出温和 cytotoxicity。Retardant 房间周期和禁止的压力纤维表示被观察由在腐蚀期间释放的 Zn ²⁺ 的高集中导致了。当粘住的血小板显示出稍微激活的形态学时， Zn 合金的溶血比率比 1% 低。一般来说，商业 Zn 合金与纯 Zn 相比拥有有希望的机械性质，适当腐蚀率，显著地改进的 biocompatibility 和好 hemocompatibility。基于商业 Zn 合金开发可被细菌破坏的金属是可行的。

英文摘要：

In this work, three widely used commercial Zn alloys （ZA4-1, ZA4-3, ZA6-1 ） were purchased and pre- pared by hot extrusion at 200℃. The microstructure, mechanical properties, corrosion behaviors, biocompatibility and hemocompatibility of Zn alloys were studied with pure Zn as control, Commercial Zn alloys demonstrated increased strength and superb elongation compared with pure Zn. Accelerated corrosion rates and uniform corrosion morphologies were observed in terms of commercial Zn alloys due to galvanic effects between Zn matrix and α-Al phases. 100% extracts of ZA4-1 and ZA6-1 alloys showed mild cytotoxicity while 50% extracts of all samples displayed good biocompatibility. Retardant cell cycle and inhibited stress fibers expression were observed induced by high concentration of Zn^2＋ releasing during corrosion. The hemolysis ratios of Zn alloys were lower than 1% while the adhered platelets showed slightly activated morphologies. In general, commercial Zn alloys possess promising mechanical properties, appropriate corrosion rates, significantly improved biocompatibility and good hemocompatibility in comparison to pure Zn. It is feasible to develop biodegradable metals based on commercial Zn alloys.

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