欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的研究遗传性癫痫大鼠（Tremor，TRM）海马中p-ERK、ERK、p-p38和p38蛋白的表达。方法以正常Wistar大鼠为对照组，PCR技术鉴定基因突变癫痫模型鼠TRM。提取大鼠海马组织后，应用免疫印迹法，检测大鼠海马中P-ERK、ERK、p-p38和p38的蛋白表达。结果与正常Wistar大鼠相比，TRM鼠海马中P-ERK与P-ERK／ERK蛋白表达量升高，而ERK蛋白表达量不变；TRM鼠海马中p-p38与P-p38／p38蛋白表达量高于正常Wistar大鼠，而p38蛋白表达量不变。结论TRM鼠海马中P-ERK与P-p38表达上调，可能与TRM癫痫发病机制相关。
英文摘要：
Objective To detect the changes of p-ERK, ERK, p-p38 and p38 in the hippocampus of genetic epileptic rats （Tremor, TRM）. Methods TRM rats were identified by PCR. Wistar rats and TRM rats were divided into control and model groups respectively. The expressions of p-ERK, ERK, p-p38 and p38 proteins were detected by Western blot. Results The expression levels of p-ERK, p-ERK/ERK, p-p38 and p-p38/p38 proteins in hippocampus were increased in TRM rats than in control group, but with no difference for ERK and p38 between control and model groups. Conclusion The overexpression of p-ERK and p-p38 proteins in the hippocampns of Tremor rats indicates that these signal pathways might be involved in the pathogenesis of epilepsy.
同期刊论文项目
同项目期刊论文
Altered expression of Neuropeptide Y, Y1 and Y2 Receptors, but not Y5 Receptor, within hippocampus a
Nonylphenol disrupts the cardio-protective effects of 17 beta-estradiol on ischemia/reperfusion inju
The Ca2+-dependent interaction of calpastatin domain L with the C-terminal tail of the Cav1.2 channe
Nonylphenol disrupts the cardio-protective effects of 17β-estradiol on ischemia/reperfusion injury i
Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction dur
Lobe-related concentration- and Ca2+-dependent interactions of calmodulin with C- and N-terminal tai
Abnormal changes in voltage-gated sodium channels Na(V)1.1, Na(V)1.2, Na(V)1.3, Na(V)1.6 and in calm
Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocyt
The up-regulation of voltage-gated sodium channels subtypes coincides with an increased sodium curre
期刊信息
位置：