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中文摘要：
目的基于小型猪的生理特点及循环系统与人类极为相似的特征，通过药物对其造模，建立一种新型的脉诊动物教学模型并对其进行评价。方法选用中华实验用成年小型猪6只（体重20±1．6kg，选取心率〈100次/min）。采用戊巴比妥钠麻醉，定位取脉位置，切脉后，用NX-8型脉诊仪同步采取正常脉图、二导心电图，血流动力学参数，血流变学指标。耳大静脉心得安注射液及葡聚糖T-500静脉给药进行造模，观察造模后一般情况（心率、皮肤颜色）及指下脉形变化，同步描记脉图及二导心电图，涩变后记录数值：不同时间点的心率变化；主波高（HB）、升支斜率（Sup）、降支斜率（Sdown）、降中峡位置（即降中峡高，主波高HE/HB）、升支时间，脉波周期（TAB/TAG）、主波峰时间，脉波周期（TB/TAG）；并采集造模后血流动力学及血流变学各项参数。结果6头小型猪均造模成功，指下感觉涩变明显；脉图变化显著；与造模前相比HB、Sup、Sdown、HE/HB、TAB/TAG、TB/TAG差异均有显著性（除SdownP〈0．05外，其余均P〈0．01）。血流动力学及血流变学相关参数差异也均有显著。讨论通过运用小型猪建立涩脉模型成功、方法可靠，小型猪应用于脉诊教学实验方法简便、损伤小、可重复运用，有充分的可行性，以此为基础可以建立多种脉诊模型，以补充脉诊实验教学中的空白。
英文摘要：
Objective Since mini-pigs have similar characteristics with human physiological features and circulatory system, the aim of this study was to establish and evaluate a new animal unsmooth pulse model by using chemical drugs and to use the new model as a teaching model. Methods Six Chinese mini-pigs （5-6 months old with 20 ± 1.6 kg weight and heart rate lower than 100 per minutes） were included in this experiment. Pentobarbital sodium was administered intraperitonealy for anesthesia. After localization of the pulse site, a NX-8 multifunctional sphygmograph was used to obtain normal pressure sphygmogram and ECG Ⅱ Propranolol and dextran T-500 were injected into the medial greater vein in the ear to produce the required pulse diagnosis model. The general condition （heart rate, skin color ） and finger＇s pulse changes in the pigs were observed simultaneously with the recording by NX-8 multifunctional sphygmograph and ECG Ⅱ The height of B wave （ HB ）, mean slope up （S up） ,mean slope down （S down） ,interval between point A and E wave （HE/HB） ,time of slope up/pulse rate, time of B wave/pulse rate （TB/TAG） were recorded. The values of the heart rate at 3^rd minute,5^th minute, 10^th minute, 15^th minute ,20＇h minute and 25＇h minute, and the values of hemodynamie and hemorheologieal parameters were also recorded. Result The required unsmooth pulse model was sueeessfully established in six mini-pigs. It was eleady observed that the normal pulse was changed into unsmooth pulse by pulse diagnosis with fingers. The sphygmogram changes in HB, S up, S down, HE/HB ,TAB/TAG, TB/TAG were significantly different in comparison with the values before model establishment. （except of S down P 〈 0.05, all the rest values were P 〈 0.01 ）. Remarkable changes of the hemodynamie and hemorheologie parameters were also observed. Discussion An unsmoofll pulse model has been successfully established in mini-pigs. This model can be used as a convenient, feasible, less-altered and repeatable tool in
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