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中文摘要：
目的以银杏二萜内酯葡胺注射液生产制造过程中产生的银杏叶废渣为试材，优化聚戊烯醇和总黄酮的综合提取工艺。方法采用L9（3^4）正交试验法，先考察预浸时间、提取时间、提取温度、颗粒过筛对石油醚提取聚戊烯醇效果的影响，再考察乙醇浓度、料液比、预浸时间、提取时间对总黄酮提取效果的影响，确定了最优的银杏叶药渣中聚戊烯醇和总黄酮的综合提取工艺。结果最佳优化工艺为银杏叶药渣粉碎过3号筛，加入10倍量石油醚预浸0．5h、40℃热回流提取2次，每次1h，提取液合并浓缩至无醚味，得聚戊烯醇提取物。石油醚处理后的银杏叶药渣干燥后，加入20倍量95％乙醇，热回流提取2次，每次0．5h，提取液合并浓缩干燥，得总黄酮提取物。结论该方法简单易行，适用于银杏叶水提后的药渣中聚戊烯醇及总黄酮的提取，为其利用效率提升和工业化生产提供参考。
英文摘要：
OBJECTIVE Taking dregs of Ginkgo Folium from ginkgo diterpene lactone meglumine injection production process as material, to optimize the extraction technology of total flavonoids and polyprenols, METHODS The L9 （34 ） orthog- onal test method was carried out to investigate the effects of pre-leaching time, extraction time, extraction temperature and particle sieving on the effect of polypentenols extract by petroleum ether. Ethanol concentration, solid-liquid ratio, extraction time and extraction time on the extraction efficiency of total flavonoids were also investigated. The optimal comprehensive ex- traction process of polyprenols and total flavonoids in the dregs of Ginkgo Folium was chosen. RESULTS The dregs of Gink- go Folium was crushed and sieved through 50 mesh, then soaked in petoleum ether for 0.5 h, extracted by reflux at 40 ℃ for 1 h twice. The filtrates were combined and concentrated without ether flavor to be polypentenols extract. The dregs after pe- troleum ether treatment were dried. 20 times of 95 % ethanol were added and extracted by reflux for 0.5 h twice. The filtrates were combined and dried to be dry extract as total flavonoids extract. CONCLUSION The method was simple and easy for the extraction of polyprenols and total flavonoids from dregs of Ginkgo Foliurn after water extracting, which provides a reference for the utilization efficiency and industrial production.
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