东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

尿mALB、RBP、CysC及其联合检测在Ⅱ型糖尿病肾病早期诊断中的临床意义

ISSN号：1673-4130
期刊名称：《国际检验医学杂志》
时间：0
分类：R587.2[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
作者机构：广东省佛山市第二人民医院检验科,528000
相关基金：佛山市医学科研基金项目（2015313）; 佛山市医学重点专科培育项目（Fspy3-2015022）.

关键词： Ⅱ型糖尿病, 糖尿病肾病, 尿微量清蛋白, 视黄醇结合蛋白, 胱抑素C, type 2 diabetes mellitus, diabetic nephropathy, urine microalbumin, retinol binding protein, cystatin C

中文摘要：

目的探讨尿微量清蛋白（mALB）、视黄醇结合蛋白（RBP）和胱抑素C（CysC）及其联合检测在Ⅱ型糖尿病肾病（DN）早期诊断中的应用价值。方法收集该院2014年6月至2015年12月住院的DN患者92例（DN组）和体检健康者90例（对照组）,对所有受试者的尿mALB、尿RBP和尿CysC水平进行检测,并对结果进行统计学分析。结果DN组患者的尿mALB、尿RBP和尿CysC水平均显著高于对照组,差异均有统计学意义（P〈0.05）。三项指标中,尿mALB检测DN的阳性率最高,为94.57%,三项联合检测的阳性率（97.83%）显著高于各项单独检测,差异有统计学意义（P〈0.05）。三项指标联合检测的灵敏度、特异度、阳性预测值、阴性预测值和Youden指数均高于各项单独检测。ROC曲线结果显示,尿mALB诊断DN的AUC为0.732,诊断阈值为43.58mg/L;尿RBP的AUC为0.685,诊断阈值为1.47mg/mL;尿CysC的AUC为0.701,诊断阈值为1.42mg/L,联合检测的AUC为0.928。结论尿mALB、尿RBP和尿CysC为反映肾脏损伤的较好指标,三者联合检测可提高诊断DN的阳性率、灵敏度和特异度。监测糖尿病患者的尿mALB、尿RBP和尿CysC水平,对诊断糖尿病早期肾损伤的发生、发展和DN的预防、治疗和延缓疾病的进程具有重要意义。

英文摘要：

Objective To investigate the application value of urine microalbumin（mALB）,retinol binding protein（RBP）and cystatin C（CysC）and their combined detection in early diagnosis of type 2diabetic nephropathy（DN）.Methods Ninety-two inpatients with DN（DN group）and 90 people undergoing the physical examination（control group）in our hospital from June 2014 to December 2015 were collected.Urine mALB,RBP and CysC were detected in all subjects and detection results were analyzed statistically.Results The levels of urine mALB,RBP and CysC in the DN group were significantly higher than those in the control group,the differences all had statistical significance（P〈0.05）.Among 3indicators,the positive rate of urine mALB for detecting DN was highest（94.57%）,while which of 3-index combined detection was 97.83%,and significantly higher than that of single detection,the difference was statistically significant（P〈0.05）.The sensitivity,specificity,positive predictive value,negative predictive value and Youden index of 3-index combined detection were all higher than those of single index.The ROC curve showed that AUC of urine mALB for diagnosing DN was 0.732,the diagnostic cut-off value was 43.58mg/L,AUC of urine RBP was 0.685,the diagnostic cut-off value was 1.47mg/mL,AUC of urine CysC was 0.701,the diagnostic cut-off value was 1.42mg/L,while AUC of combined detection was 0.928.Conclusion Urine mALB,RBP and CysC are better indexes reflecting renal injury.Their combined detection will increase the positive rate,sensitivity and specificity for diagnosing DN.So monitoring the levels of urine mALB,RBP and CysC has an important significance to diagnosing the occurrence and development of DN early renal injury and prevention,treatment and delaying progress of DN.

同期刊论文项目