中文摘要：

羟基磷灰石，多孔钛复合植入体．骨界面上骨组织的早期生长状况对该时期它们的界面结合强度有较大影响．羟基磷灰石／多孔钛复合植入体被植入新西兰大白兔股骨窠申，经1，3和5周生长后，进行推出试验，并采用FE-SEM和EDS对试验后样品的断裂面形貌和表面成分进行了研究。结果显示，剪切强度随着植入时间的增加较快递增．同时随着时间的增加，植入体．骨的断裂界面上，组织形态发生了较大的变化，表现为组织变得致密以及厚度增加，并逐渐钙化，形成骨组织。

英文摘要：

The bone growth state has a great influence on interfacial bonding strength between hydroxyapatite coating/porous titanium implants and natural bone. In the present study, these implants were implanted transversely into the femoral condyles of the adult New Zealand white rabbits, and after postoperative periods of 1, 3 and 5 weeks, implant fixation strength was evaluated using a push-out test. The SEM and EDS were employed to investigate the fracture surface of the selected pushed-out implants and the composition of newborn tissues, respectively. The results show that the fixation strength increased rapidly and there were great differences in the morphologies of newborn tissues with the increasing implantation time. A large number of matrixes formed and adhered to the surface of HA coating after 1 week implantation, and an increased thickness of tissues （dense matrix and mineralized tissue） doped with some smaller fractured newborn bones was observed on the fracture surfaces after 3 weeks implantation. A denser tissue layer formed on the fracture surfaces, concurrently with larger fractured newborn bones after 5 weeks implantation. The EDS results approved the formation of newborn bones.