中文摘要：

为解决传统人工胫骨平台假体个体匹配性差，结构强度与生物活性难统一等问题，提出了定制化复合增强型人工胫骨平台系统的设计制造方法。采用解剖学建模技术设计出外形匹配，内含三维网状构架的复合假体模型，利用快速成型技术制造出假体的树脂原型，并分别通过精密铸造和粉末烧结技术制造出钛合金胫骨平台和大段多孔陶瓷人工骨。结果显示，该方法能快速而精确地制造出形状复杂的人工胫骨平台系统，是实现假体定制化制造的有利保证；通过将金属假体和多孔陶瓷人工骨复合，解决了载重部位大段骨缺损的修复问题。临床应用表明，该假体能与对侧关节匹配运动，通过将机械重建与生物重建相结合可实现受损关节的功能重建。

英文摘要：

In order to improve the individual matching and balance the mechanical strength with bioactivity for artificial tibial tray substitute, a custom-made design and fabrication approach was presented. Anatomical modelling was adopted to construct the composite substitute with biomimetic shape and three-dimensional interconnected microstructures. Rapid prototyping （RP） was employed to build the resin mold, based on which the titanium-alloy tibial tray and porous ceramic artificial bone was fabricated via quick casting and powder sintering techniques. Results showed that this method enabled to fabricate the complex artificial tibial tray system rapidly and provided a new way to repair large segment bone defects for loading site via composing titanium-alloy prosthesis and porous ceramic artificial bone. The clinical example verified the efficiency of the composite tibial substitute to restore the damaged joint function via combining mechanical and biological reconstruction.