中文摘要：

建立一种新型松质骨缺损的动物模型,观察和评价新型多孔β-磷酸三钙（β-TCP）对该骨缺损的修复能力。成年中国青山羊双侧股骨下端、胫骨上端制备腔隙性松质骨缺损（直径10mm、深20mm）,以颗粒型多孔β-TCP（A组）、粉末型多孔β-TCP（B组）进行修复,同时设立冻干异体骨（C组）和空白对照组（D组）。术后4周、12周、24周进行X线片、CT及组织学以观察和评价骨缺损修复情况。结果表明D组不能自行愈合;X线、CT示24周时A、B、C组均骨性愈合,图像数据分析示A组和C组、B组和C组间有统计学差异（P〈0.05）;组织学示A、B、C三组4周新骨开始长入,24周骨缺损基本修复,4周、12周、24周三组新生骨面积比分别为（6.82±0.84）%、（6.68±1.13）%、（19.98±1.32）%,（16.32±2.21）%、（16.88±2.43）%、（38.63±3.31）%,（37.67±5.52）%、（39.11±6.43）%、（55.67±4.38）%,统计学分析示C组修复效果好于A组、B组（P〈0.05）,A组、B组间无差异（P〉0.05）。该骨缺损模型稳定、可靠,可较好得模拟一些临床中的腔隙性骨缺损环境;新型多孔β-TCP可良好修复该腔隙性松质骨缺损。

英文摘要：

To design a new model of lacunar cancellous bone defect and assess the osteogenesis of pourous β-tricalcium phosphate（β-TCP） on the model, lacunar cancellous bone defects were established at inferior segments of femurs and superior of tibias bilaterally of each goat. Pourousβ-TCP particle （group A）, pourousβ-TCP powder （group B）, freeze-dried cancellous bone allograft particel（ group C） were filled in bone defects, there was also a group without implant served（group D）. Osteogenesis of each group was evaluated with X-ray, computerized tomo-graphy, histology and histomorphometry at 4th, 12 h and 24th week postoperative. It have found that group D couldn＇t heal spontaneusly throughout 24 weeks. The X-ray density and computer tomography （CT） density measured in all defects of group C were higher than those of groups A and group B （ P 〈 0.05 ）, whereas group A and group B did not differ from each other. Histomorphometrical measurements were performed for the whole defect area at the end of 4th, 12th and 24th week. The bone penetration ratio in group C was higher than group A and group B, groups A and groups B did not differ from each other. Such a stable and reliable model of lacunar cancellous bone defect can supply a similar enviroment which appear in clinical tate new bone in growth, biomaterials degradation and enhance surgeries. The material used in our study can facilibone defect healing in big animal models.