中文摘要：

莱姆病是20世纪70年代发现的一种由硬蜱叮咬传播的自然疫源性人兽共患传染病。严重威胁人类健康，引起全球性的关注。伯氏疏螺旋体是莱姆病的病原体。目前莱姆病在很多方面的研究已经取得显著进展，但其致病机理尚不完全清楚，主要原因可能是莱姆病病原体及其成分直接作用、炎性细胞因子作用以及自身免疫因素的影响。对近年有关莱姆病致病机理的研究进展进行概述。

英文摘要：

Lyme disease was found by the tick-bome spirochaete Borrelia burgdorferi infection zoonosis in the 1970s, which has been a serious threat to human. Borrelia burgdorferi is the pathogen of Lyme disease. Recent researches show that Lyme disease has been made great progress in many respects, but the pathogen- esis is not entirely clear, the main reason may be the direct effects of the pathogen and the composition, the role of inflammatory cytokines, and the autoimmune factors. Research progresses of pathogenesis of Lyme disease are reviewed.