莱姆病是由伯氏疏螺旋体引起,即莱姆病螺旋体引起的多系统感染性疾病。伯氏疏螺旋体本身并不具有生物活性,不能分泌毒力因子,其唯一的致毒因子为外膜脂蛋白。其中,外膜脂蛋白C(O spC)相对于外膜蛋白A(O spA)以及鞭毛蛋白来说,其分子量较大。并且,最重要的一点是O spC在宿主体内能引起早期免疫反应;同时O spC抗原性强,免疫O spC后可以检测出,血清中抗体的浓度明显上升。因此,本文对目前国内外对O spC的研究进行了综述。
Lyme disease spirochaetes cause infectious of multiple system diseases. But Borrelia burgdorferi can not secrete toxins, its virulence factors mainly are outer surface lipoproteins(Osp). Among them, Osp C can cause immune response early in the host. At the same time, Osp C has strong immunogenicity, increased concentration of antibody in serum can be detected after immunized by Osp C. The study progress of Osp C was summarized here.