中文摘要：

莱姆病是一种人兽共患病,已严重威胁人类健康,成全球公共卫生问题,引起全球关注.伯氏疏螺旋体是莱姆病病原体,通过蜱叮咬传播而引起莱姆病,其表面存在的膜蛋白具有免疫性和致病性.BmpA（Borreliaburgdorferi membrance protein A）是伯氏疏螺旋体的主要抗原之一,为层粘连蛋白结合蛋白,是莱姆关节炎的重要致病因子,对蛋白功能、诊断应用和莱姆关节炎致病机理三方面的研究进展进行概述.

英文摘要：

Lyme disease,a global health concern,is a zoonosis,which has been a serious threat to human.The spirochete Borrelia burgdorferi that is transmitted by the bite of hard tick（Ixodidae） is the pathogen of Lyme disease.Borrelia burgdorferi contains many membrane proteins with immungenicity and pathogenicity.Recent researches show that BmpA is an dominant immune protein of Borrelia burgdorferi,a laminin-binding protein,and an arthritogennic factor.Research progresses of BmpA protein in biological function,Lyme arthritis pathogenesis and diagnosis of lyme disease are reviewed.