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中文摘要：
目的考察盐酸多西环素缓释片的体外释放度与其在犬体内吸收的相关性。方法采用紫外分光光度法在268nm波长处检测并计算盐酸多西环素缓释片10h的累积释放度；采用高效液相色谱法检测beagle犬（n=6）121服盐酸多西环素缓释片48h内的血药浓度，以wagner－Nelson法计算其体内吸收分数fa，考察fla与体外溶出速率R的相关性。结果盐酸多西环素缓释片8h的累积释放度〉90％；犬体内的fa值在6h达最高值；盐酸多西环素缓释片体内吸收分数fa与体外释放速率ft的关系式为：fa=0．8586ft＋23．712（r=0．975，P〈0．01）。结论盐酸多西环素缓释片体外释放与在犬体内吸收的相关性良好。
英文摘要：
The dissolution rate in vitro and bioavailability in beagle dogs of doxycycline hydrochloride sustained-release tablets were investigated. The correlations of the dissolution in vitro and absorption in vivo were evaluated. Methods The drug dissolution in vitro was measured by UV spectrophotometer. The plasma concentration in beagle dogs was measured by HPLC. The correlation of dissolution in vitro and bioavailability in vivo were studied by the Wagnner-Nelson method. Results The relationship between the dissolution fraction ft and the absorption fraction fa was fa=0.8586ft q- 23.712 （r=0.975, P〈0.01）. Conclusion The correlation between dissolution in vitro and absorption in vivo of doxycycline hydrochloride sustained-release tablets was good.
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