位置：成果数据库 > 期刊 > 期刊详情页
生物药剂学分类系统在难溶性药物处方设计中的应用
  • ISSN号：1001-5213
  • 期刊名称：《中国医院药学杂志》
  • 时间：0
  • 分类：R94[医药卫生—药剂学;医药卫生—药学]
  • 作者机构：[1]南京工业大学药学院,江苏南京211816
  • 相关基金：国家自然科学基金资助项目（编号：81170492）;江苏省高校自然科学研究面上项目（编号：10KJB350002）
作者： 叶雯[1], 王永禄[1], 李学明[1]
关键词： 生物利用度, 生物药剂学分类系统, 难溶性药物
中文摘要：

基于药品的生物药剂学分类系统探讨能够提高难溶性药物溶解度、溶出度和口服生物利用度的可行处方方案，并对代表性难溶性药物的处方进行了综述。方法：通过文献分析，总结能够提高难溶性药物溶解度的方法。结果：生物药剂学分类系统可为有难度的药物开发工作提供指导。结论：增加难溶性药物溶解度和/或溶解速率是提高其口服生物利用度的有效方法。更好地了解药物的理化性质和各个处方方案的限制，才能有针对性地开发难溶性药物的处方。

同期刊论文项目
化疗药和中药与转铁蛋白纳米载体的设计及逆转白血病耐药的机制研究
期刊论文 75 会议论文 2 著作 3
同项目期刊论文
Crizotinib as a personalized alternative for targeted anaplastic lymphoma kinase rearrangement in pr
Brentuximab vedotin for treatment of relapsed or refractory malignant lymphoma: results of a systema
Brentuximab vedotin for relapsed or refractory Hodgkin's lymphoma
Effects of magnetic nanoparticles of Fe3O4 combinated with gambogic acid on apoptosis of SMMC-7721 c
Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery sys
Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin.
Prophylaxis and treatment of acute lymphoblastic leukemia relapse after allogeneic hematopoietic ste
The functional role of microRNA in acute lymphoblastic leukemia: relevance for diagnosis, differenti
Multiplex analysis of tumor multidrug-resistance genes expression with photonic suspension array.
Study on the release of fenofibrate nanosuspension in vitro and its correlation with in situ intesti
A solid-state electrochemiluminescence sensing platform&nbs
Handy, rapid and multiplex detection of tumor markers basedon encoded silica–hydrogel hybrid beads a
The interleukin-10-1082A>G polymorphism and lymphoma&
藤黄酸逆转肿瘤多药耐药的实验研究进展
Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic effic
Biocompatibility assessment of polyethylene glycol-poly L-lysine-poly lactic-co-glycolic acid(PEG-PL
藤黄酸逆转肿瘤多药耐药的实验研究进展
Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and
ABCG2介导的肿瘤多药耐药
Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells i
AGEs与其受体相互作用与K562及K562/A02细胞耐药性
PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via int
Polymorphisms in XPC provide prognostic information in acute myeloid leukemia
Biocompatibility Assessment of Polyethylene Glycol-Poly L-Lysine-Poly Lactic-Co-Glycolic Acid Nanopa
CFSE荧光负染法检测RAW264.7小鼠单核巨噬细胞白血病细胞摄取超顺磁性氧化铁纳米粒子
非诺贝特纳米混悬剂大鼠体内药动学及其与在体肠吸收动力学相关性
IL-10基因3575T>A位点多态性和淋巴瘤易感性的荟萃分析
晚期糖基化终末产物和汉防己甲素对K562及K562/A02细胞增殖的影响
Systematic review and meta-analysis of prospective studies for ECP treatment in patients with steroi
载柔红霉素和汉防己甲素的聚乳酸羟基乙酸-聚赖氨酸-聚乙二醇纳米粒的制备
Hepatocellular carcinoma presenting as thoracic spinal canal metastasis with no clinical primary foc
Superselective arterial embolization of the superior mesenteric artery for the treatment of gastroin
藤黄酸对白血病K562/A02细胞的耐药逆转作用
磁性纳米Fe3O4颗粒对藤黄酸诱导肝癌细胞凋亡的影响
髓系/前体NK细胞急性白血病及髓系/NK细胞急性白血病的回顾和进展
体外光化学疗法治疗慢性移植物抗宿主病的研究进展
Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome
Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanopart
Siltuximab (CNTO 328): a promising option for human malignancies
Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1/vascular endothelial growth fact
转铁蛋白-转铁蛋白受体在乳腺癌靶向治疗中的应用
晚期糖基化终产物对人肝癌细胞HepG2增殖的影响
非诺贝特纳米混悬剂大鼠在体肠吸收动力学研究
Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for Hep
Reversal of multidrug resistance by cisplatin-loaded magnetic Fe3O4 nanoparticles in A549/DDP lung c
Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K56
The interleukin-10-1082A > G polymorphism and lymphoma risk: A meta-analysis
Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells.
Handy, rapid and multiplex detection of tumor markers based on encoded silica-hydrogel hybrid beads
Primary malignant lymphoma of the uterus and broad ligament: a case report and review of literature
Umbilical cord blood transplantation supplemented with the infusion of mesenchymal stem cell for an
The role of dasatinib in the management of chronic myeloid leukemia
Severe thrombocytopenia after dasatinib treatment in a patient with Philadelphia chromosome-positive
骨髓增殖性肿瘤研究新进展
Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines
药物纳米结晶的研究进展
药物纳米结晶的生物药剂学特性概述
液相色谱-质谱联用法同时测定大鼠血浆中柔红霉素和汉防己甲素的浓度
共研磨法改善枸橼酸莫沙必利的体外溶出度
盐酸多西环素缓释片体内外相关性研究
新藤黄酸的抗肿瘤作用研究进展
Association of polymorphisms of cytosine arabinoside- metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia
ABCG2介导的肿瘤多药耐药
乙醇脱氢酶共存固相电致化学发光生物传感器对p53基因的检测
IL-10基因3575T〉A位点多态性和淋巴瘤易感性的荟萃分析
期刊信息
  • 《中国医院药学杂志》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学技术协会
  • 主办单位:中国药学会
  • 主编：陈华庭
  • 地址：武汉市汉口胜利街155号
  • 邮编：430014
  • 邮箱：pharmacy@vip.163.com
  • 电话：027-82836596
  • 国际标准刊号：ISSN：1001-5213
  • 国内统一刊号：ISSN：42-1204/R
  • 邮发代号:38-50
  • 获奖情况:
  • 曾获中国药学会优秀期刊二等奖,中国科协优秀期刊三等奖,湖北省优秀期刊奖
  • 国内外数据库收录:
  • 美国国际药学文摘,美国化学文摘（网络版）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:53772