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中文摘要：
简述了药物纳米结晶的特有性质及生产技术，讨论其对细胞吸收和毒性的影响。该剂型可以口服、透皮和静注途径给药。其中，经静注给药后，药物纳米结晶可被巨噬细胞吸收而富集于肝脏，再缓释释放，从而达到降低全身毒性的作用。但器官内药物浓度过高也会引起毒性反应。
英文摘要：
The unique characteristics, preparation method, cellular uptake and cytotoxicity of drug nanocrystals are discussed in this paper. This formulation can be administrated by oral, transdermal and intravenous injection routes. Among these routes, the drug nanocrystals after iv administration can be enriched into liver by phagocytosis with macrophages, then release slowly within a certain time. It can reduce the systemic side effects but increase the local toxicity.
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