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中文摘要：
以样品指纹向量与对照指纹向量的多元化学组分间存在线性函数关系为基础，引入相关系数r、斜率a、截距b及线性定性相似度SＬ、线性定量相似度MＬ等概念，建立线性指纹定量法（linearly quantified fingerprint method，LQFM）模型以定性、定量控制中药质量。用高效液相色谱－二极管阵列检测法（HPLC—DAD）同时测定了10批人参归脾丸（Renshen GuipiWan，RSGPW）分别在203、228和325nm下的高效液相色谱指纹图谱，运用LQFM理论模型，鉴定RSGPW质量。LQFM能显著区别不同来源的产品，同一厂家产品质量控制一致。鉴定结果与已知的系统指纹定量法评价结果对比，LQFM对中药多元化学成分的复杂系统能实现客舰的定性、定髓评价。多波长指纹图谱能最大限度地兼顾中药各成分的紫外吸收特征，对中药质量控制具有更全面和可靠的特点。
英文摘要：
The theoretical model of linearly quantified fingerprint method （LQFM） for qualita- tive and quantitative control traditional Chinese medicine （TCM） has been developed based on the relationship of linear function between a sample and the reference fingerprint vector, as the concepts of correlation coefficient r, slope a, intercept b, linearly qualitative similarity SL, line- arly quantitative similarity ML and so on were introduced into the study. The high performance liquid chromatography coupled with diode array detector （DAD） was used to simultaneously obtain chromatograms of ten batches of Renshen Guipi Wan （RSGPW） at 203, 228 and 325 nm, separately. The model of LQFM was applied to evaluate the three-wavelength fingerprints for the quality control of RSGPW, it could obviously distinguish RSGPW from different resources and the results showed the quality was almost consistent from the same manufacture. The results of LQFM were compared with those of the systematically quantified fingerprint method （ SQFM）, a known method for quality control of TCM. It proved that LQFM can evaluate quali- tatively and quantitatively the complex system of TCM which is composed of diverse chemical components. The quality control can be better and more reliable by multiple-wavelength finger- prints which give full consideration of the ultraviolet absorption characteristics of different com- ponents.
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Qualitative and quantitative assessment of the HPLC fingerprints of Ginkgo biloba extract by the inv
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