从整体论、系统论和复杂科学的角度论述了中药指纹图谱学体系的构成背景和核心任务。中药指纹图谱学体系具有体系科学性质,是从系统性和整体性角度研究中药(包括植物药)的物质基础和作用机制以及药代动力学规律和相关制剂技术的崭新学科。该体系以中药指纹图谱信息学为核心和桥梁,包括中药指纹图谱测试学、中药指纹图谱质控学、中药指纹图谱谱效学、中药指纹药物动力学、中药指纹药剂学和中药生物指纹图谱学。该体系的研究需采用复杂科学和体系科学的理论和方法,突破线性思维和还原分析,强调宏观和系统的有机综合,应用数学科学原理和方法来开辟中药创制的新模式。中药指纹图谱学的理论体系和方法是解析中药的主导技术和实现中药现代化的核心力量,该体系理论和技术的成熟及完善可为现代中药创制提供强有力的理论和技术支撑。中药指纹图谱学体系的最终目的是为人类和有益生物研制出疗效显著、安全、可控的现代化中药。
The background and main task of the system of TCM fingerprintology from holism,systematology and complexity science are elaborately discussed.The fingerprintology of TCM is a novel system,in which the pharmacologic substance bases,mechanism and the law of pharmacokinetics on TCM(herbal medicine)and technologies for other related preparations are systematically and integrally studies.The core position and bridge effect of the fingerprint informatics of TCM were set forth.The system of TCM fingerprintology comprises the fingerprint testology,the fingerprint quality controlology,the fingerprint pharmacodynamics,the fingerprint pharmacokinetic,the fingerprint-pharmaceutics and the biofingerprintology of TCM.The theories and methods of complexity science and system science should be applied in the study of the system.The new mode of the innovative development of TCM is established by breaking through the linear thinking and reduction analysis,highly emphasizing mathematical principles and methods from a integral and systematic point of view.The theories and methods of the TCM fingerprintology are the main forces in the analysis of the leading technology and modernization of TCM.The maturity and perfection of the theories and methods will powerfully support the development of innovative TCM.The ultimate purpose of the system of the TCM fingerprintology is to develope effective,safety and controllable TCMs for human and other beneficial organisms.